Distribution of xanthine oxidase and xanthine dehydrogenase specificity types among bacteria
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چکیده
منابع مشابه
Xanthine oxidase and xanthine dehydrogenase from an estivating land snail.
During arousal from estivation in land snails, Otala lactea, active metabolic functions are restored within minutes and oxygen consumption increases dramatically. During the transition from the hypoxic conditions of estivation to normoxia it is possible that xanthine oxidase (XO) in hepatopancreas contributes to the observed lipid peroxidation. Using a fluorometric assay that is based on the ox...
متن کاملPhosphorylation of xanthine dehydrogenase/oxidase in hypoxia.
The enzyme xanthine oxidase (XO) has been implicated in the pathogenesis of several disease processes, such as ischemia-reperfusion injury, because of its ability to generate reactive oxygen species. The expression of XO and its precursor xanthine dehydrogenase (XDH) is regulated at pre- and posttranslational levels by agents such as lipopolysaccharide and hypoxia. Posttranslational modificatio...
متن کاملThe species distribution of xanthine oxidase.
1. The distribution of xanthine oxidase in blood and tissues of various animals was studied by means of a radioactive assay capable of detecting 10(-7) unit of enzyme. The method was shown to be applicable to tissues with a high uricase content. 2. Of 16 mammalian species examined, six had low concentrations of xanthine oxidase in the serum. In six non-mammalian species, no activity was detecte...
متن کاملClxi. the Distribution of Xanthine Oxidase I
IN a previous paper by Morgan, Stewart and Hopkins [1922] it was shown that " xanthine oxidase " acts as a typical dehydrase in the sense of Wieland. Tissue preparations which contain the enzyme oxidise the bases hypoxanthine and xanthine to uric acid anaerobically in the presence of methylene blue, the dye being reduced to its colourless leuco-compound. The use of this anaerobic technique, com...
متن کاملCrystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: structure-based mechanism of conversion.
Mammalian xanthine oxidoreductases, which catalyze the last two steps in the formation of urate, are synthesized as the dehydrogenase form xanthine dehydrogenase (XDH) but can be readily converted to the oxidase form xanthine oxidase (XO) by oxidation of sulfhydryl residues or by proteolysis. Here, we present the crystal structure of the dimeric (M(r), 290,000) bovine milk XDH at 2.1-A resoluti...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1977
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.130.3.1175-1191.1977